Abstract
This paper reports testing 15 polyether triterpenes with a squalene carbon skeleton for inhibitory effects on type 2A protein phosphatase. Two compounds, 16-hydroxydehydrothyrsiferol 10 and thyrsenol B 14, exhibited significant inhibitory action at a concentration of 10 microM. Comparison with thyrsiferyl-23-acetate 1 showed that a similar spatial disposition for the hydroxy group around C-15 or C-16 was the structural feature shared by these metabolites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Okadaic Acid / pharmacology
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Phosphoprotein Phosphatases / antagonists & inhibitors*
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Rhodophyta / chemistry
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Squalene / analogs & derivatives*
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Squalene / isolation & purification
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Squalene / pharmacology*
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Structure-Activity Relationship
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
Substances
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Enzyme Inhibitors
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Triterpenes
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Okadaic Acid
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Squalene
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Phosphoprotein Phosphatases